Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly Soluble Drug Norfloxacin

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dc.contributor.authorYadav, P
dc.contributor.authorKumari, S
dc.contributor.authorYadav, A
dc.contributor.authorBhardwaj, P
dc.contributor.authorMaruthi, M
dc.date.accessioned2024-04-17T09:19:31Z
dc.date.available2024-04-17T09:19:31Z
dc.date.issued2023-07
dc.description.abstractNorfloxacin (NFX), an important antibacterial fluoroquinolone, is a class IVdrugaccording to thebiopharma ceutics classification system(BCS) and has low solubility and permeabilityissues.Suchpoorphysicochemicalpropertiesofdrug molecules leadtopoordeliveryandareof seriousconcerntothe pharmaceutical industryforclinicaldevelopment.Wepresenthere aconceptuallynewapproachtodeliverNFX,byloadingthedrug moleculeontheporousplatformofabiocompatiblemetal−organic framework(MOF),MIL-100(Fe).Theloadingof thedrugonthe MOFleadingtoNFX@MIL-100(Fe)wascharacterizedbyFourier transforminfrared(FTIR),UV−visiblespectroscopy, thermogravi metric analyses (TGA), and nitrogen adsorption studies. Controlledexperiments resulted in thehigh loadingof thedrug molecule(∼20wt%)alongwiththedesiredsustainedrelease.Wecouldfurthercontrol thereleaseofnorfloxacinbycoatingdrug loadedMIL-100(Fe) with PEG, PEG{NFX@MIL-100(Fe)}. Both drug delivery systems (DDSs), NFX@MIL-100(Fe) and PEG{NFX@MIL-100(Fe)},weretestedfortheirbiocompatibilitythroughtoxicitystudies.TheDDSsarebiocompatibleandshow insignificant cytotoxicity, as revealed by cell viability studies through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1437
dc.language.isoenen_US
dc.titleBiocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly Soluble Drug Norfloxacinen_US
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