Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly Soluble Drug Norfloxacin
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Date
2023-07
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Abstract
Norfloxacin (NFX), an important antibacterial
fluoroquinolone, is a class IVdrugaccording to thebiopharma
ceutics classification system(BCS) and has low solubility and
permeabilityissues.Suchpoorphysicochemicalpropertiesofdrug
molecules leadtopoordeliveryandareof seriousconcerntothe
pharmaceutical industryforclinicaldevelopment.Wepresenthere
aconceptuallynewapproachtodeliverNFX,byloadingthedrug
moleculeontheporousplatformofabiocompatiblemetal−organic
framework(MOF),MIL-100(Fe).Theloadingof thedrugonthe
MOFleadingtoNFX@MIL-100(Fe)wascharacterizedbyFourier
transforminfrared(FTIR),UV−visiblespectroscopy, thermogravi
metric analyses (TGA), and nitrogen adsorption studies.
Controlledexperiments resulted in thehigh loadingof thedrug
molecule(∼20wt%)alongwiththedesiredsustainedrelease.Wecouldfurthercontrol thereleaseofnorfloxacinbycoatingdrug
loadedMIL-100(Fe) with PEG, PEG{NFX@MIL-100(Fe)}. Both drug delivery systems (DDSs), NFX@MIL-100(Fe) and
PEG{NFX@MIL-100(Fe)},weretestedfortheirbiocompatibilitythroughtoxicitystudies.TheDDSsarebiocompatibleandshow
insignificant cytotoxicity, as revealed by cell viability studies through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide(MTT)assay.