Browsing by Author "Yadav, S"
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Item Biomedical applications of metal oxide nanoparticles in aging and age‑associated diseases(2021-06) Yadav, S; Maurya, PMetal oxide nanoparticles are known to exhibit unique properties such as catalyzing the neutralization of superoxide anions, hydroxyl radicals, hydrogen peroxides and behave as antioxidant enzymes. Oxidative stress, damage and chronic inflam mation are major causes and consequences of aging and age-associated disorders. With the increasing popularity of metal oxide nanoparticles, they have been applied in various age-related pathologies using their antioxidant property. Metal oxide nanoparticles have been used as diagnostic, therapeutic, and as theranostics. This review summarizes the applications of metal oxide nanoparticles in aging and age-associated disorders such as cardiovascular diseases, diabetes, cancer, neurodegenera tive disorders. Oxidative stress plays a central role in the activation of inflammatory pathways, disturbing the mitochondrial function, decreasing the telomere length and leading the cell towards senescence or death. Oxidative damage is the common pathway in the progression of aging and related diseases. Metal oxide nanoparticles scavenge or precisely detect the gener ated reactive oxygen species, hence applied in both diagnostics and therapeutics.Item A new parameter estimation method for the extended power Lindley distribution based on order statistics, with application(2024-06) Kumar, D; Kumar, M; Yadav, S; Goyal, AIn this paper, we propose inference procedures for the estimation of parameters by using or der statistics. First, we derive some new expressions for single and product moments of the order statistics from the extended power Lindley distribution. We then use these moments to obtain the best linear unbiased estimates (BLUEs) of the location and scale parameters based on Type-II right-censored samples. A real data set is analysed to illustrate the flexibility and importance of the model.Item Recent advances in the protective role of metallic nanoparticles in red blood cells(2021-12) Yadav, S; Maurya, PThe interaction of nanoparticles with the biological system has increased with the increasing popularity of nanomedicines. Red blood cells (RBCs) are very sensitive, and abundant cells in the blood. They are highly prone to oxidative damage due to constant interaction with oxygen itself, foreign particles in the blood, and the lack of repair mechanism. The cell mem brane of RBCs undergoes lipid peroxidation, protein oxidation, and heme degradation which results in altered membrane permeability, changes in the morphology, and functioning of RBCs. The nanoparticles induce oxidative stress, hemolysis, morphological changes, membrane deformability, and alterations in hemoglobin structure in RBCs. In this review, the effects of metallic nanoparticles and their modifications on the physiology, and life span of RBCs are discussed. The detailed analy sis of the antioxidant enzymes-like activity of metal nanoparticles is expected to highlight the beneficial use of these metal nanoparticles in RBCs against oxidative stress and the development of new biosafe nanodrugs.