Browsing by Author "Pandey, Manisha"

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    Azithromycin-based Albumin Nanoparticles Loaded Oral Fast dissolving Films as Superheroes in the Fight against Strep Throat
    (2026) Pandey, Manisha
    Streptococcal pharyngitis, strep throat, is a bacterial infection induced by group A Streptococcus. Azithromycin (AZI) is used as the second-line drug for its treatment. The study’s goal was to formulate AZI-based albumin nanoparticles loaded on fast oral dissolving films, which would help reduce the dosage and dosing frequency of the drug by enhancing its local effect in the affected area. The desolvation process was utilized for the synthesis of albumin nanoparticles, while the solvent casting approach was applied for the formulation of the oral fast-dissolving films (OFDF). A 3-factor and 3-level CCD was implemented to ascertain the influence of critical material attributes on the critical quality attributes of the nanoparticles employing Design-Expert software. The optimized nanoparticles exhibited particle dimension, zeta potential, and entrapment efficiency of 250.6 ± 19.6 nm, -0.656 mV, and 98.67% ± 0.002, respectively. The in vitro release of the optimized formulation demonstrated an initial burst release of 18.11% ± 0.0024 within the first 2 hours, and subsequently, a sustained release profile was observed, with 96% ± 0.15 of the drug over 36 h. The AZI-loaded albumin nanoparticles loaded oral fast-dissolving films demonstrated a drug release of 95% ± 0.659 within 1 h, and the ex vivo permeation via goat buccal mucosa further revealed a flux of 45.36 mg/h. cm2. Moreover, the formulation was assessed for its antibacterial potency towards Streptococcus aureus, revealing a substantial zone of inhibition measuring 38 mm ± 0.152 compared to the marketed oral tablet. The findings collectively point to the formulation’s efficacy in addressing strep throat, suggest ing its potential as a viable treatment option for this condition. Further preclinical studies can be performed to ensure its successful translation.
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    Multifunctional approaches of cubosome-integrated thermoresponsive gels for intranasal brain targeting: Innovations, therapeutic potential, and challenges
    (2026) Pandey, Manisha
    Neurodegenerative disorders, such as cognitive disabilities and dementia, have nowadays become a global burden, distressing millions of elderly people worldwide. It is characterized by progressive loss of neurons in the central nervous system, affecting higher cortical centers and ultimately impacting the social life of the patients. Conventional treatment approaches to such neurological complications primarily involve systemic drug delivery through either oral or parenteral routes of administration. However, limited brain bioavailability due to the restrictive properties of the blood-brain barrier, systemic side effects, biotransformation of the drug, and limited ability to maintain therapeutic concentrations in the CNS pose a challenge in targeted therapy. In recent years, cubosomes, nanostructured lipid-based carriers of an internally bi-continuous cubic phase, have emerged as a novel drug delivery system, which are capable of encapsulating both hydrophilic and lipophilic drugs. These unique structured nanocarriers possess favourable physical properties, including high surface area and ther modynamic stability, which make them a potential tool for controlled and targeted drug delivery systems. With intranasal administration, cubosomes offer the ability to bypass the BBB due to the use of the olfactory and trigeminal neural pathways, achieving direct brain targeting of the therapeutics. Thus, this review aims to provide an overview of the nose-to-brain transport mechanisms, based on the anatomical and physiological basis following intranasal delivery of cubosomes integrated into thermoresponsive in situ gels. The review also focuses on their potential therapeutic applications in the treatment of neurodegenerative diseases. In addition, the re view also presents formulation challenges and strategies to address them, providing insight into the future possibilities of cubosome-based gels as a new non-invasive brain-targeted therapy.
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    Nanoemulsion and nanoemulgel-based carriers as advanced delivery tools for the treatment of oral diseases
    (2025) Pandey, Manisha
    Oral diseases rank among the most widespread ailments worldwide posing significant global health and economic chal lenges affecting around 3.5 billion people, impacting the quality of life for affected individuals. Dental caries, periodontal disease, bacterial and fungal infections, tooth loss and oral malignancies are among the most prevalent global clinical disorders contributing to oral health burden. Traditional treatments for oral diseases often face challenges such as poor drug bioavailability, breakdown of medication in saliva, inconsistent antibiotic levels at the site of periodontal infection as well as higher side effects. However, the emergence of nanoemulgel (NEG) as an innovative drug delivery system offers promising solutions where NEG combines the advantages of both nanoemulsions (NEs) and hydrogels providing improved drug solubility, stability, and targeted delivery. Due to their minuscule size and ability to control drug release, NEGs hold promise for improving treatment of oral diseases, where versatility of these delivery systems makes them suit able for various applications, including topical delivery in dentistry. This review concisely outlines the anatomy of the oral environment and investigates the therapeutic potential of NE-based gels in oral disorder treatment. It thoroughly examines the challenges of drug delivery in the oral cavity and proposes strategies to improve therapeutic efficacy, drawing attention to previous research reports for comparison. Through comprehensive analysis, the review highlights the promising role of NEGs as a novel therapeutic approach for oral health management via research advancements and their clinical transla tion. Additionally, it provides valuable insights into future research directions and development opportunities in this area.
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    Tocotrienol in the treatment of topical wounds: Recent updates
    (Pharmaceutics, 2022) Pandey, Manisha; Nair, Anroop B.; Gorain, Bapi; Jacob, Shery; Shinu, Pottathil; Aldhubiab, Bandar; Almuqbil, Rashed M.; Elsewedy, Heba S.; Morsy, Mohamed A.
    Healing wounds is an important attempt to keep the internal higher organs safe. Complications in topical wound healing may lead to the formation of scars, which can affect the patient’s quality of life. Although several approaches are ongoing in parallel in the exploration of natural compounds via advanced delivery, in this article, an attempt has been made to highlight tocotrienol. Tocotrienol is a natural form of vitamin E and has shown its potential in certain pharmacological activities better than tocopherol. Its antioxidant, anti-inflammatory, cell signal-mediating effects, angiogenic properties, management of scar, and promotion of wound environment with essential factors have shown potential in the management of topical wound healing. Therefore, this review has aimed to focus on recent advances in topical wound healing through the application of tocotrienols. Challenges in delivering tocotrienols to the topical wound due to its large molecular weight and higher logP have also been explored using nanotechnological-based carriers, which has made tocotrienol a potential tool to facilitate the closure of wounds. Exploration of tocotrienol has also been made in human volunteers for biopsy wounds; however, the results are yet to be reported. Overall, based on the current findings in the literature, it could be inferred that tocotrienol would be a viable alternative to the existing wound dressing components for the management of topical wounds.