Nanoemulsion and nanoemulgel-based carriers as advanced delivery tools for the treatment of oral diseases
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Date
2025
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Abstract
Oral diseases rank among the most widespread ailments worldwide posing significant global health and economic chal
lenges affecting around 3.5 billion people, impacting the quality of life for affected individuals. Dental caries, periodontal
disease, bacterial and fungal infections, tooth loss and oral malignancies are among the most prevalent global clinical
disorders contributing to oral health burden. Traditional treatments for oral diseases often face challenges such as poor
drug bioavailability, breakdown of medication in saliva, inconsistent antibiotic levels at the site of periodontal infection
as well as higher side effects. However, the emergence of nanoemulgel (NEG) as an innovative drug delivery system
offers promising solutions where NEG combines the advantages of both nanoemulsions (NEs) and hydrogels providing
improved drug solubility, stability, and targeted delivery. Due to their minuscule size and ability to control drug release,
NEGs hold promise for improving treatment of oral diseases, where versatility of these delivery systems makes them suit
able for various applications, including topical delivery in dentistry. This review concisely outlines the anatomy of the oral
environment and investigates the therapeutic potential of NE-based gels in oral disorder treatment. It thoroughly examines
the challenges of drug delivery in the oral cavity and proposes strategies to improve therapeutic efficacy, drawing attention
to previous research reports for comparison. Through comprehensive analysis, the review highlights the promising role of
NEGs as a novel therapeutic approach for oral health management via research advancements and their clinical transla
tion. Additionally, it provides valuable insights into future research directions and development opportunities in this area.