Tocotrienol in the treatment of topical wounds: Recent updates
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Pharmaceutics
Abstract
Healing wounds is an important attempt to keep the internal higher organs safe. Complications
in topical wound healing may lead to the formation of scars, which can affect the patient’s
quality of life. Although several approaches are ongoing in parallel in the exploration of natural
compounds via advanced delivery, in this article, an attempt has been made to highlight tocotrienol.
Tocotrienol is a natural form of vitamin E and has shown its potential in certain pharmacological
activities better than tocopherol. Its antioxidant, anti-inflammatory, cell signal-mediating effects,
angiogenic properties, management of scar, and promotion of wound environment with essential
factors have shown potential in the management of topical wound healing. Therefore, this review has
aimed to focus on recent advances in topical wound healing through the application of tocotrienols.
Challenges in delivering tocotrienols to the topical wound due to its large molecular weight and
higher logP have also been explored using nanotechnological-based carriers, which has made tocotrienol
a potential tool to facilitate the closure of wounds. Exploration of tocotrienol has also been
made in human volunteers for biopsy wounds; however, the results are yet to be reported. Overall,
based on the current findings in the literature, it could be inferred that tocotrienol would be a viable
alternative to the existing wound dressing components for the management of topical wounds.
Description
Keywords
tocotrienols; topical wound; nanotechnology; challenges; growth factor; wound closure; angiogenesis