Browsing by Author "Maurya, Pawan Kumar"

Now showing 1 - 6 of 6
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    A comparative study of chemically synthesized and Camellia sinensis leaf extract-mediated silver nanoparticles
    (3 Biotech, 2019) Kumar, Varun; Wadhwa, Ridhima; Kumar, Naresh; Maurya, Pawan Kumar
    Silver nanoparticles (AgNPs) are amongst the most fascinating nanomaterials which have been extensively synthesized by chemical reduction and biological method using enzymes, microorganisms and plant extracts. In our study, an aqueous extract of green tea was used as a stabilizing and reducing agent for AgNPs synthesis. The synthesized AgNPs were characterized by dynamic light scattering, UV–visible (UV–Vis) spectroscopy and scanning electron microscopy. These AgNPs were evaluated for antimicrobial activity and photocatalytic dye degradation. The AgNPs showed antibacterial activity against E. coli, S. aureus and S. pyogenes with 6 mm, 5 mm and 8 mm zone of inhibition, respectively. Our work also focused on methylene blue degradation in aqueous solution using AgNPs as catalyst which shows 65% of dye degradation. An absorbance peak of 427–437 nm was observed using UV–Vis spectrophotometer. Our study proves that the AgNPs show potent antimicrobial activity against pathogenic bacteria. At room temperature, AgNPs possess rapid, effective and steady catalytic activity in cationic organic dye degradation. The high catalytic activity of AgNPs can be employed in industries and water purification. Our study confirmed that green-synthesized AgNPs are eco-friendly and non-toxic.
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    Health benefits of quercetin in age-related diseases
    (Molecules, 2022) Maurya, Pawan Kumar; Deepika
    Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10–12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.
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    Oxidative Stress: Diagnostic Methods and Applications in Medical Science
    (Springer Press, 2017) Maurya, Pawan Kumar; Chandra, Pranjal
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    Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles
    (3 Biotech, 2019) Wadhwa, Ridhima; Aggarwal, Taru; Chandra, Pranjal; Yadav, Pooja; Maurya, Pawan Kumar; Kumari, Vandana; Reddy, Boda Sai Charan
    Blood and the linings of blood vessels may be regarded as a fifth tissue type. The human body contains 5 × 109 red blood cells (RBCs) per ml, a total of 2.5 × 1013 cells in the 5 l of blood present in the body. With an average lifetime of 125 days, human RBCs are destroyed by leukocytes in the spleen and liver. Nowadays red blood cells are extensively used to study various metabolic functions. Nanoparticles (NP) are being widely accepted for drug delivery system. This review summarizes the red blood cells, NPs and their characteristics on the basis of the RBC components along with drug delivery systems through RBCs. Further, we also discussed that how erythrocytes can be used as an efficient in vitro model for evaluating the efficacy of various nanocomposite materials.