Health benefits of quercetin in age-related diseases
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Date
2022
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Molecules
Abstract
Polyphenols are the known group of phytochemicals that essentially consists of phenolic
rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites
perform a protective function in plants from environmental and biological stress. When consumed
as a human diet these are also known to prevent various age-associated diseases. Polyphenols
are known to possess antioxidant properties and protect against oxidative stress. The literature
survey was carried out using databases such as PubMed, Science direct and Springer. The research
articles from last 10–12 years were selected for this review based on its relevancy with the topic.
The articles selected was mainly focused on quercetin and its health benefits. The present review
highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring
polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion
is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant
properties and is considered to have a protective function against aging. It is known to be present in
both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative,
anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily
cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various
in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of
quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been
carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related
disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals.
Properties of quercetin can be further explored in various other disorders. Nanoformulations and
liposomal formulations of quercetin can be made to treat other age associated diseases.
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Keywords
polyphenols; antioxidant; quercetin; neurodegeneration; diabetes; cancer