Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles
Loading...
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
3 Biotech
Abstract
Blood and the linings of blood vessels may be regarded as a fifth tissue type. The human body contains 5 × 109 red blood cells
(RBCs) per ml, a total of 2.5 × 1013 cells in the 5 l of blood present in the body. With an average lifetime of 125 days, human
RBCs are destroyed by leukocytes in the spleen and liver. Nowadays red blood cells are extensively used to study various
metabolic functions. Nanoparticles (NP) are being widely accepted for drug delivery system. This review summarizes the
red blood cells, NPs and their characteristics on the basis of the RBC components along with drug delivery systems through
RBCs. Further, we also discussed that how erythrocytes can be used as an efficient in vitro model for evaluating the efficacy
of various nanocomposite materials.
Description
Keywords
Red blood cells · Nanoparticles · Drug delivery system · Fabrication