Molecular mechanism of iron transport systems in vibrio
Loading...
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Pure and Applied Microbiology
Abstract
The ability to acquire iron from the environment is often an important virulence factor for pathogenic
bacteria and Vibrios are no exception to this. Vibrios are reported mainly from marine habitats
and most of the species are pathogenic. Among those, the pathogenic vibrios eg. V cholerae, V.
parahaemolyticus, V. vulnificus causes foodborne illnesses. Vibrios are capable of producing all
different classes of siderophores like hydroxamate (aerobactin), catecholate (vibriobactin, fluvibactin),
carboxylate (vibrioferrin), and amphiphilic (amphibactin). Every different species of vibrios are capable
of utilizing some endogenous or xenosiderophores. Being Gram-negative bacteria, Vibrios import iron
siderophore via TonB dependent transport system and unlike other Gamma proteobacteria these usually
possess two or even three partially redundant TonB systems for iron siderophore transport. Other than
selected few iron siderophores, most pathogenic Vibrios are known to be able to utilize heme as the
sole iron source, while some species are capable of importing free iron from the environment. As per
the present knowledge, the spectrum of iron compound transport and utilization in Vibrios is better
understood than the siderophore biosynthetic capability of individual species.
Description
Keywords
Iron Transport, Siderophore, Vibrios, Iron Acquisition, Ferrisiderophore