Antibacterial action of acriflavine hydrochloride for eradication of the gastric pathogen Helicobacter pylori

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dc.contributor.authorTehlan, A
dc.contributor.authorKarmakar, B
dc.contributor.authorPaul, S
dc.contributor.authorKumar, R
dc.contributor.authorKaur, I
dc.date.accessioned2024-04-15T09:35:21Z
dc.date.available2024-04-15T09:35:21Z
dc.date.issued2020-10
dc.description.abstractHelicobacter pylori, a type 1 carcinogen, accounts for numerous gastric cancer-related deaths worldwide. Repurposing existing drugs or developing new ones for a combinatorial approach against increasing antimicrobial resistance is the need of the hour. This study highlights the efficacy of acriflavine hydrochloride (ACF-HCl) in inhibiting the growth of H. pylori reference strain and antibiotic-resistant clinical isolates at low concentrations. ACF-HCl inhibits H. pylori growth at MIC value 10 times less than that in Escherichia coli, another Gram-negative bacteria. Furthermore, ACF-HCl demonstrates synergistic effect with clarithromycin, a commonly used antibiotic against H. pylori. ACF-HCl treatment also eradicates H. pylori infection in the mice model efficiently. Our in vitro data indicate that bacterial membrane is the prime target. The novel action of ACF-HCl against antibiotic-resistant clinical isolates, synergistic effect with the conventional antibiotic clarithromycin and eradication of H. pylori from infected mice highlight the potential of ACF-HCl as a promising therapeutic agent against H. pylori by itself as well as for combinatorial therapy.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1390
dc.language.isoenen_US
dc.titleAntibacterial action of acriflavine hydrochloride for eradication of the gastric pathogen Helicobacter pylorien_US
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