Simple and solvent free practical procedurefor chalcones: An expeditious, mild andgreener approach

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dc.contributor.authorAdnan, Duha
dc.contributor.authorSingh, Bijender
dc.contributor.authorMehta, Surinder,Kumar
dc.contributor.authorKumar, Vinod
dc.contributor.authorKataria, Ramesh
dc.date.accessioned2023-05-02T05:36:30Z
dc.date.available2023-05-02T05:36:30Z
dc.date.issued2020
dc.description.abstractAn extremely simple, expeditious and greener synthetic method for a variety of chalcone derivatives (3) under mild and solvent free reaction conditions has been developed. The present protocol discloses the use of p-toluenesulfonic acid (p-TSA) as a solid phase organocatalyst which accelerates the Claisen–Schmidt condensation reaction dramatically under mild conditions. Various aryl aldehydes (1) were treated with differently substituted aryl ketones (2) in the presence of p-TSA at 50–60 C to yield the desired products in a very short period of reaction time. Mild reaction conditions, clean reaction media, expulsion of hazardous solvents, simple work-up, exclusive formation of products in high yields without side products, and easy purification are advantages of the present methodology.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1075
dc.language.isoenen_US
dc.publisherCurrent Research in Green and Sustainable Chemistryen_US
dc.subjectChalcones Organocatalysis Solvent free approach Green chemistry p-TSA Solid phase synthesisen_US
dc.titleSimple and solvent free practical procedurefor chalcones: An expeditious, mild andgreener approachen_US
dc.typeArticleen_US
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