Simple and solvent free practical procedurefor chalcones: An expeditious, mild andgreener approach
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Current Research in Green and Sustainable Chemistry
Abstract
An extremely simple, expeditious and greener synthetic method for a variety of chalcone derivatives (3) under
mild and solvent free reaction conditions has been developed. The present protocol discloses the use of p-toluenesulfonic
acid (p-TSA) as a solid phase organocatalyst which accelerates the Claisen–Schmidt condensation
reaction dramatically under mild conditions. Various aryl aldehydes (1) were treated with differently substituted
aryl ketones (2) in the presence of p-TSA at 50–60 C to yield the desired products in a very short period of
reaction time. Mild reaction conditions, clean reaction media, expulsion of hazardous solvents, simple work-up,
exclusive formation of products in high yields without side products, and easy purification are advantages of the
present methodology.
Description
Keywords
Chalcones Organocatalysis Solvent free approach Green chemistry p-TSA Solid phase synthesis