Modulation of gut-microbiota through probiotics and dietary interventions to improve host health
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Date
2024-02
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Abstract
Dietary patterns play an important role in regards to the modulation and control of the gut microbiome composition and func tion. The interaction between diet and microbiota plays an important role in order to maintain intestinal homeostasis, which
ultimately affect the host's health. Diet directly impacts the microbes that inhabit the gastrointestinal tract (GIT), which then
contributes to the production of secondary metabolites, such as short-chain fatty acids, neurotransmitters, and antimicrobial
peptides. Dietary consumption with genetically modified probiotics can be the best vaccine delivery vector and protect cells
from various illnesses. A holistic approach to disease prevention, treatment, and management takes these intrinsically linked
diet-microbes, microbe–microbe interactions, and microbe–host interactions into account. Dietary components, such as fiber
can modulate beneficial gut microbiota, and they have resulting ameliorative effects against metabolic disorders. Medical interventions, such as antibiotic drugs can conversely have detrimental effects on gut microbiota by disputing the balance
between Bacteroides and firmicute, which contribute to continuing disease states. We summarize the known effects of various
dietary components, such as fibers, carbohydrates, fatty acids, vitamins, minerals, proteins, phenolic acids, and antibiotics on
the composition of the gut microbiota in this article in addition to the beneficial effect of genetically modified probiotics and
consequentially their role in regards to shaping human health.