Grewia asiatica Linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: Fabrication,characterization and anthelmintic evaluation
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Date
2022
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Acta Pharmaceutica Sciencia
Abstract
The current study was planned to formulate the Grewia asiatica Linn. root extract
loaded herbal formulation and evaluated its potential for in vitro anthelmintic activity.
The root extract of Grewia asiatica Linn. was standardized by HPTLC using
quercetin and naringenin, as a marker compound. The extract was formulated into
a novel microparticulate and nanosuspension dosage form based on the Eudragit
S100. The prepared dosage forms were characterized by particle size, morphology,
and in vitro release behavior. Further, the comparative evaluation of dosage form
revealed the presence of higher in vitro anthelmintic activity in nanosuspension as
compared to conventional suspension and microparticulate dosage form.
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Keywords
Grewia asiatica; nanosuspension; microparticles; suspension; anthelmintic