Green mycosynthesis of silver nanoparticles exhibiting antimalarial activity
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Date
2024-07
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Abstract
In the present study, different parameters, affecting the growth of Thermomyces lanuginosus
BJMDU1 and extracellular synthesis of silver nanoparticles (AgNPs), were studied. Culture extract
of thermophilic mould Thermomyces lanuginosus BJMDU1 showed potential in green synthesis
of silver nanoparticles when the fungus was grown in a sucrose yeast extract medium (pH 8.0)
at 45°C. Mycosynthesis of AgNPs was enhanced in the presence of light using 2 mM AgNO3 and
200 µl of culture extract at 50°C. The reaction parameters significantly improved the synthesis
of AgNPs. Techniques like UV-Vis & FT-IR spectroscopy, X-ray diffraction, transmission electron
microscopy and dynamic light scattering were used to characterise AgNPs. Biogenic nanoparti cles showed an absorption peak at 430 nm having 80 nm size. Biogenic AgNPs showed potent
antibacterial and antiplasmodial activity with no haemolysis up to 40 µg/ml. The p-nitrophenol
was catalytically reduced to p-aminophenol by AgNPs. Therefore, green mycosynthesised AgNPs
could be used in the therapeutics and remediation of environmental pollutants.