Browsing by Author "Kumar, Vinod"
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Item Approaches towards the synthesis of 5-aminopyrazoles(Beilstein Journal of Organic Chemistry, 2011) Kumar, VinodItem Novel acetohydrazide pyrazolederivatives: Design, synthesis,characterization and antimicrobial activity(Asian Journal of Chemistry, 2019) Kumar, VinodEleven acetohydrazide linked pyrazole derivatives were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. 6b, 6c and 6d were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives as compared to other groups present in the ring. Hence, among compounds 6b-c, compound 6d could be explored further against other microbes to prove its vitality.Item Phenols and Polyphenols: Promise and Peril to Human Health(Bentham Science Publishers, 2018) Kumar, VinodItem Simple and solvent free practical procedure for chalcones: An expeditious, mild and greener approach(Elsevier_Current Research in Green and Sustainable Chemistry 3, 2020) Kumar, VinodItem Simple and solvent free practical procedurefor chalcones: An expeditious, mild andgreener approach(Current Research in Green and Sustainable Chemistry, 2020) Adnan, Duha; Singh, Bijender; Mehta, Surinder,Kumar; Kumar, Vinod; Kataria, RameshAn extremely simple, expeditious and greener synthetic method for a variety of chalcone derivatives (3) under mild and solvent free reaction conditions has been developed. The present protocol discloses the use of p-toluenesulfonic acid (p-TSA) as a solid phase organocatalyst which accelerates the Claisen–Schmidt condensation reaction dramatically under mild conditions. Various aryl aldehydes (1) were treated with differently substituted aryl ketones (2) in the presence of p-TSA at 50–60 C to yield the desired products in a very short period of reaction time. Mild reaction conditions, clean reaction media, expulsion of hazardous solvents, simple work-up, exclusive formation of products in high yields without side products, and easy purification are advantages of the present methodology.Item Synthesis of Some Hippuric Acid Substrate Linked Novel Pyrazoles as Antimicrobial Agents(ASIAN JOURNAL OF CHEMISTRY, 2019-01-31) Kumar, Vinod