Browsing by Author "Kumar, Vinod"

Now showing 1 - 7 of 7
  • Thumbnail Image
    Item
    Approaches towards the synthesis of 5-aminopyrazoles
    (Beilstein Journal of Organic Chemistry, 2011) Kumar, Vinod
  • No Thumbnail Available
    Item
    Light-assisted synergistic effect of Zn-MOF@rGO nanocomposite for methylene blue degradation and toxicity analysis to water reclamation
    (2025) Kumar, Vinod
    Integrating reduced graphene oxide (rGO) onto nanostructured Metal-organic frameworks (MOFs) offers a transformative strategy to amplify light harvesting in photocatalysis, suppressing charge carrier recombination and thus enhancing degradation processes. In this work, we develop a hybrid material (PUC-8@rGO) by incorporating rGO sheets onto Zn-MOF (PUC-8). The crystals of PUC-8 were prepared using the solvothermal method, and the nanocomposite material was synthesized using the wet-impregnation procedure. To measure the photocatalytic activity, prepared samples were utilized to degrade the methylene blue (MB) dye on exposure to visible light. Several factors affecting photocatalytic activity were examined, including pH, amount of dye, catalyst dosage and irradiation time to optimize photocatalysis. Remarkably, PUC-8@rGO exhibits an unprec edented 7 to 8-fold rate increase constant compared to PUC-8 and rGO, credited to its augmented BET surface area and a narrow band gap, which effectively prolongs electron-hole (e /h + ) recombination. Degradation pathway and intermediate product analysis were done using the LC-MS technique. The BOD (biological oxygen demand) and COD (chemical oxygen demand) levels in the water significantly reduced following treatment with PUC-8@rGO, falling within permissible limits for environmentally safe discharge. Furthermore, seed germination assays attest to low phytotoxicity, endorsing treated water for crop irrigation. Encouragingly, PUC-8@rGO displays potent cytotoxicity (IC 50 = 0.125 mg/mL) against the human ovarian cancer cell line, SKOV3 as compared to HaCat (non-tumerous) cells (IC 50 = 0.25 mg/mL), holding promising biomedical implications.
  • Thumbnail Image
    Item
    Novel acetohydrazide pyrazolederivatives: Design, synthesis,characterization and antimicrobial activity
    (Asian Journal of Chemistry, 2019) Kumar, Vinod
    Eleven acetohydrazide linked pyrazole derivatives were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. 6b, 6c and 6d were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives as compared to other groups present in the ring. Hence, among compounds 6b-c, compound 6d could be explored further against other microbes to prove its vitality.
  • Thumbnail Image
    Item
    Phenols and Polyphenols: Promise and Peril to Human Health
    (Bentham Science Publishers, 2018) Kumar, Vinod
  • Thumbnail Image
    Item
    Simple and solvent free practical procedure for chalcones: An expeditious, mild and greener approach
    (Elsevier_Current Research in Green and Sustainable Chemistry 3, 2020) Kumar, Vinod
  • Thumbnail Image
    Item
    Simple and solvent free practical procedurefor chalcones: An expeditious, mild andgreener approach
    (Current Research in Green and Sustainable Chemistry, 2020) Adnan, Duha; Singh, Bijender; Mehta, Surinder,Kumar; Kumar, Vinod; Kataria, Ramesh
    An extremely simple, expeditious and greener synthetic method for a variety of chalcone derivatives (3) under mild and solvent free reaction conditions has been developed. The present protocol discloses the use of p-toluenesulfonic acid (p-TSA) as a solid phase organocatalyst which accelerates the Claisen–Schmidt condensation reaction dramatically under mild conditions. Various aryl aldehydes (1) were treated with differently substituted aryl ketones (2) in the presence of p-TSA at 50–60 C to yield the desired products in a very short period of reaction time. Mild reaction conditions, clean reaction media, expulsion of hazardous solvents, simple work-up, exclusive formation of products in high yields without side products, and easy purification are advantages of the present methodology.
  • Thumbnail Image
    Item
    Synthesis of Some Hippuric Acid Substrate Linked Novel Pyrazoles as Antimicrobial Agents
    (ASIAN JOURNAL OF CHEMISTRY, 2019-01-31) Kumar, Vinod