Browsing by Author "Kumar, Tarun"

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    Clinical Analysis of Resemblance and Dissimilarities of Glucagon-like Peptide-1 Receptor Agonists: Therapeutic Approach Towards the Management of Diabetes Mellitus
    (2025) Kumar, Tarun
    Abstract: One of the classes of injective antidiabetic agents includes Glucagon-like peptide-1 recep tor agonists (GLP-1RA) which ameliorate glycemia and numerous atherosclerosis-related factors in individuals prone to Type 2 diabetes mellitus (T2-DM) disorder. A R T I C L E H I S T O R Y Received: September 13, 2023 Revised: November 06, 2023 Accepted: November 14, 2023 DOI: 10.2174/0115748855276929231218053337 Current Drug Therapy Methods: The review paper targeted the role of GLP-1RA in managing DM. The literature published during the last decades in several data-based searches (PubMed, Scopus, ScienceDirect) was re viewed and compiled the therapeutic uses of GLP-1 RA in the management of DM. In this review, we have discussed GLP-1RA and its role in the management of diabetes mellitus. Results and Discussion: Disrupted homeostasis marks insulin resistance and β-cell deterioration as two major indications of T2-DM. β-cells failure (~80% of functioning of β-cell) and insulin resistance in the liver and muscles are primarily susceptive to physiological defects. GLP-1RAs if administered for a prolonged period also cause a loss in weight through the activation of receptors of GLP-1 found in hypothalamic satiety centers which control appetite and decrease intake of calories. They not only assist in controlling blood glucose but also improve β- cell function and post–diabetic conditions namely hyperlipidemia, obesity, and hypertension. Conclusion: It was concluded that GLP-1RA has a new therapeutic approach to the management of DM. Hence, GLP-1RA provides distinctive and innovative evolution for the treatment of T2-DM.
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    Grewia asiatica Linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: Fabrication,characterization and anthelmintic evaluation
    (Acta Pharmaceutica Sciencia, 2022) Kumar, Tarun; Pahwa, Rimpy; Ahuja, Munish
    The current study was planned to formulate the Grewia asiatica Linn. root extract loaded herbal formulation and evaluated its potential for in vitro anthelmintic activity. The root extract of Grewia asiatica Linn. was standardized by HPTLC using quercetin and naringenin, as a marker compound. The extract was formulated into a novel microparticulate and nanosuspension dosage form based on the Eudragit S100. The prepared dosage forms were characterized by particle size, morphology, and in vitro release behavior. Further, the comparative evaluation of dosage form revealed the presence of higher in vitro anthelmintic activity in nanosuspension as compared to conventional suspension and microparticulate dosage form.