Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly Soluble Drug Norfloxacin
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Date
2023-07
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Abstract
ABSTRACT: Norfloxacin (NFX), an important antibacterial
fluoroquinolone, is a class IV drug according to the biopharma ceutics classification system (BCS) and has low solubility and
permeability issues. Such poor physicochemical properties of drug
molecules lead to poor delivery and are of serious concern to the
pharmaceutical industry for clinical development. We present here
a conceptually new approach to deliver NFX, by loading the drug
molecule on the porous platform of a biocompatible metal−organic
framework (MOF), MIL-100(Fe). The loading of the drug on the
MOF leading to NFX@MIL-100(Fe) was characterized by Fourier
transform infrared (FTIR), UV−visible spectroscopy, thermogravi metric analyses (TGA), and nitrogen adsorption studies.
Controlled experiments resulted in the high loading of the drug
molecule (∼20 wt %) along with the desired sustained release. We could further control the release of norfloxacin by coating drug loaded MIL-100(Fe) with PEG, PEG{NFX@MIL-100(Fe)}. Both drug delivery systems (DDSs), NFX@MIL-100(Fe) and
PEG{NFX@MIL-100(Fe)}, were tested for their biocompatibility through toxicity studies. The DDSs are biocompatible and show
insignificant cytotoxicity, as revealed by cell viability studies through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay.