Eleven acetohydrazide linked pyrazole derivatives were designed and synthesized via condensation of acetohyadrazide with different
substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds were characterized on the basis of IR,
NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds were screened against four bacterial and two
fungal strains. Among the synthesized compounds, three compounds viz. 6b, 6c and 6d were found as efficient antimicrobial agents in
reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that
electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives as compared to other groups present in the ring.
Hence, among compounds 6b-c, compound 6d could be explored further against other microbes to prove its vitality.