Browsing by Author "Singh, R"

Now showing 1 - 7 of 7
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    2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities
    (2023-03) Singh, R; Gupta, V; Kumar, A; Singh, K
    Te nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.
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    Analyzing optimal muscle dynamics during handstands: a comprehensive investigation of skilled gymnasts
    (2024-04) Singh, R; Periyasamy, K; L, Ajithkumar
    This study aimed to evaluate the muscle dynamics involved in single and double-arm handstands performed by five skilled gymnasts, with a mean age of 23.6 ± 1.94 years. Myoware Muscle Sensor (AT-04-001) (MMS) signals were collected from three key upper limb muscles: Wrist Flexor (WF), Triceps Brachii (TB), and Lateral Deltoid (LD), all on the dominant side of the body. To facilitate data collection and processing, Internet of Things (IoT) programs were employed, utilizing Arduino IDE and Python 3.10.0 applications to connect the NodeMCU (ESP8266) via server and client code. The NodeMCU's display frequency range was set at 0–1024 Hz, with a Baud (Bd) rate of 9600 in Arduino, which is a crucial parameter for visualizing the data accurately. It continuously reads the serial and plotter monitor signals from the MMS through the A0 pin. The processed data was transmitted wirelessly by the NodeMCU, displayed on a monitor, and recorded for analysis. Participants executed three trials of their maximum handstand performance on the floor; the gymnasts peak level of 15 seconds performance was used for analysis (i.e., the middle time of the best trial; e.g., maximum performance was 45 seconds in this 16–30sec used). The observed muscle stimulation range was from a minimum of 109617 Hz to a maximum of 151292 Hz. Overall, one-arm handstands (52.79%) demonstrated better muscle activation than double-arm handstands (47.21%). The analysis revealed a statistically significant positive Correlation (r) and Probability (p) between the WF and LD (r = 0.870, p = 0.001). However, no significant correlations were observed between the WF and the TB (r = 0.507, p = 0.134) or the TB and the LD (r = 0.491, p = 0.150). To conclude, despite comparable inter-muscle contributions, the study suggests a significant association between WF and LD. Future research can build on these findings, exploring additional muscle groups and refining training protocols for performance optimization and injury prevention. This study encourages broader investigations, including more muscles in the upper and lower body, with advanced research laboratories and larger sample sizes.
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    Comprehensive scientific examination of leg length discrepancy in junior badminton players
    (2023-10) Kumar, P; Singh, R
    The objective of this research was to conduct a comprehensive analysis of Leg Length Discrepancy (LLD) among in young badminton players with the aim of mitigating back discomfort and reducing injuries in their current training environments. Numerous studies have established a connection between LLD and various musculoskeletal issues in different sports, causing asymmetrical gait and low back pain. Consequently, many players find their daily routines disrupted, leading to burnout or dropout from the sport. To assess the current situation, this study focused on 1502 young badminton players aged 9–12 from the states of Tamil Nadu and Puducherry. LLD can be challenging to diagnose and treat, especially in growing children, and various methods and equipment are available for assessment. In this research, the "Delta Leg" (DL) measuring tool was employed, measuring discrepancies from millimeters to centimeters. The 0–10 Numeric Pain Rating Scale was used to determine the level of pain. The analysis involved the application of percentage techniques (P = n × 100 / N) and Pearson correlation. The results indicated that 218 (15%) of the players had equal-length lower limbs, while 1284 (85%) exhibited LLD in varying degrees. Among the LLD players, 354 (24%) had discrepancies greater than 1 cm, 753 (50%) had discrepancies less than 1–2 cm, 171 (11%) had discrepancies less than 2–3 cm, and 6 (0.40%) had discrepancies less than 3 cm. LLD was notably prevalent among young badminton players aged 9 to 12, warranting careful attention. Even mild LLD should not be overlooked, emphasizing the importance of coaches, physiotherapists, physical education instructors, and doctors in closely monitoring players' leg mechanics. Immediate corrective actions are essential, and continuous monitoring is imperative, because LLD may necessitate intervention before reaching skeletal maturity. The use of insoles is recommended to alleviate muscular and/or joint problems and gait issues in players. Additionally, some players with equal leg lengths exhibited pronation and supination in their ankles, suggesting the need for future research to explore other lower limb issues experienced by badminton players.
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    INVESTIGATION OF ANTECEDENTS AND CONSEQUENCES OF USEFULNESS IN ONLINE TRAVEL COMMUNITIES: THE MODERATING ROLE OF DECISION MAKING STAGE
    (2023-05) Ranga, B; Singh, R; Ranga, I
    This study examines the perceived usefulness (PU) of online discourse and the decision-making behavior of users in Online Travel Communities (OTCs). Partial least squares structural equation modeling (PLS-SEM) was used on secondary data available in OTCs in the form of 852 threads to empirically test the proposed integrated model. The antecedents of the perceived usefulness of online travel communities were found to be the argument quality and credibility. These influence the PU of user generated content significantly and are helpful in information adoption in OTCs. The PU of OTC discourse positively impacts travelers' information adoption and decision-making. The current study offers implications for OTCs and online service providers for enhancing the usefulness of user-generated content in OTCs and social media sites, leading to online information use and travel decision-making. Prior literature has explored the nature and magnitude of the influence of electronic word-of-mouth (eWOM) on information adoption and intention to use information for travel purchases from users' perspectives and has investigated the PU of third-party travel sites. This paper is an effort to examine PU and decision-making by analyzing the User-Generated-Content (UGC) posted by the actual users.
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    A Review on Recent Trends and Future Developments in Electrochemical Sensing
    (2024-02) Singh, R; Gupta, R; Bansal, D; Bhateria, R
    Electrochemical methods and devices have ignited prodigious interest for sensing and monitoring. The greatest challenge for science is far from meeting the expectations of consumers. Electrodes made of two-dimensional (2D) materials such as graphene, metal−organic frameworks, MXene, and transition metal dichalcogenides as well as alternative electrochemical sensing methods offer potential to improve selectivity, sensitivity, detection limit, and response time. Moreover, these advancements have accelerated the development of wearable and point-of-care electrochemical sensors, opening new possibilities and pathways for their applications. This Review presents a critical discussion of the recent developments and trends in electrochemical sensing.
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    RNA-Seq Analysis of Developing Grains of Wheat to Intrigue into the Complex Molecular Mechanism of the Heat Stress Response
    (2022-06) Paul, S; Duhan, J; Jaiswal, S; Angadi, U; Sharma, R; Raghav, N; Gupta, O; Sheoran, S; Sharma, P; Singh, R; Rai, A; Singh, G; Kumar, D
    Heat stress is one of the significant constraints affecting wheat production worldwide. To ensure food security for ever-increasing world population, improving wheat for heat stress tolerance is needed in the presently drifting climatic conditions. At the molecular level, heat stress tolerance in wheat is governed by a complex interplay of various heat stress associated genes. We used a comparative transcriptome sequencing approach to study the effect of heat stress (5°C above ambient threshold temperature of 20°C) during grain f illing stages in wheat genotype K7903 (Halna). At 7 DPA (days post-anthesis), heat stress treatment was given at four stages: 0, 24, 48, and 120 h. In total, 115,656 wheat genes were identified, including 309 differentially expressed genes (DEGs) involved in many critical processes, such as signal transduction, starch synthetic pathway, antioxidant pathway, and heat stress-responsive conserved and uncharacterized putative genes that play an essential role in maintaining the grain filling rate at the high temperature. A total of 98,412 Simple Sequences Repeats (SSR) were identified from de novo transcriptome assembly of wheat and validated. The miRNA target prediction from differential expressed genes was performed by psRNATarget server against 119 mature miRNA. Further, 107,107 variants including 80,936 Single nucleotide polymorphism (SNPs) and 26,171 insertion/ deletion (Indels) were also identified in de novo transcriptome assembly of wheat and wheat genome Ensembl version 31. The present study enriches our understanding of known heat response mechanisms during the grain filling stage supported by discovery of novel transcripts, microsatellite markers, putative miRNA targets, and genetic variant. This enhances gene functions and regulators, paving the way for improved heat tolerance in wheat varieties, making them more suitable for production in the current climate change scenario.
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    Simulation of thermal comfort and energy demand in buildings of sub-Himalayan eastern India - Impact of climate change at mid (2050) and distant (2080) future
    (2023-02) Thapa, S; Rijal, H; Pasut, W; Singh, R
    The global warming associated with climate change predicted by the Intergovernmental Panel on Climate Change (IPCC) is expected to deteriorate the indoor climate of free-running buildings. Features like proper orientation and wall thickness are important for the design of a building that is resilient to the impact of climate change. However, the implementation of these features is sometimes difficult, especially in a rugged hilly location. A whole building simulation was per formed using DesignBuilder for an existing 3-storey free running multi-family concrete building located in the sub-Himalayan region of eastern India, for thermal comfort and energy demand during the present and the climate change scenarios of 2050 and 2080. The results show an increasing trend in the indoor operative temperature during the future climatic scenario, with the condition inside the top roof-exposed floor deteriorating the most. A decrease of 59.8% and 81.2% in the annual heating energy and an increase of 221.9% and 467.0% in the annual cooling energy were predicted for the future climate of 2050 and 2080 compared to the present. Para metric analysis performed considering orientation, wall U-value, infiltration rate and window-to wall ratios revealed that the east/south-east facing orientation would perform the best with re gard to overheating due to climate change. Further, the use of autoclaved aerated concrete (AAC) brick is recommended along with the decrease in air infiltration rate and window-to-wall ratio to improve the thermal performance of the indoor environment. In addition, we have also proposed a method to assess the under-cooling of an indoor environment.