Browsing by Author "Singh, M"

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    Amla (Emblica officinalis) alleviates doxorubicin-induced cardiotoxicity and nephrotoxicity in rats
    (2024-11) Arora, M; Singh, M; Tomar, R; Singh, L; Jangra, A
    Introduction: Doxorubicin (DOX) is a widely used anticancer drug known for its significant cardiotoxic and nephrotoxic effects. Seeking remedies to mitigate these adverse effects is crucial. This study investigates the potential of Emblica officinalis (Amla) extract, a prominent component in Chinese and Indian traditional medicine systems, in alleviating DOX-induced cardiotoxicity and nephrotoxicity. Methods: DOX (20 mg/kg i.p., once) was given to rats to cause acute cardiotoxicity and nephrotoxicity. Rats received 16 similar and cumulative doses of DOX (1.25 mg/kg, i.p.) on alternate days for chronic cardiotoxicity and nephrotoxicity. Biochemical and histological evaluations were done to confirm the onset of cardiotoxicity and nephrotoxicity. Results: The cardioprotective and nephroprotective effects of Amla extract (AE) (150 mg/kg p.o. and 300 mg/kg p.o) were evaluated in comparison to Vitamin E (25 mg/kg p.o.). The treatment with AE (300 mg/kg/day, p.o.) considerably prevented DOX-induced cardiotoxicity, nephrotoxicity, and oxidative stress by positively altering the integrity of glomeruli, restoring the tissue GSH and decreasing serum TBARS. AE (300 mg/kg) was found to be more cardioprotective and nephroprotective than Vitamin E (25 mg/kg p.o.). Discussion: It may be concluded that the induction of cardiotoxicity and nephrotoxicity in rats may be due to DOX-induced oxidative stress, and chronic treatment with AE (300 mg/kg) is an effective way to alleviate the cardiotoxic and nephrotoxic adverse effects of DOX in rats. Moreover, given Amla’s historical and contemporary significance in Chinese and Indian traditional medicine systems, its potential therapeutic role merits further exploration in clinical settings.
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    Distribution and temporal variation of total volatile organic compounds concentrations associated with health risk in Punjab, India
    (2023-07) Singh, B; Singh, M; Ulman, Y; Sharma, U
    In December 2019, a novel coronavirus disease (COVID-19) outbreak occurred due to a human respiratory virus that originated in the city of Wuhan, China. During the COVID-19 lockdown, there was a significant improve ment in the air quality across the world. We analyzed the data for BTEX over the three years (January to December 2019 to 2021) with pairwise comparison and trend analysis for pre-, during, and post-pandemic pe riods. This study demonstrates the substantial changes in the concentration of VOCs in the urban area (Punjab) due to the lockdown effects. The results indicate a substantial reduction in the mean TVOCs concentration for all the monitoring stations was found to be 8.89 ± 1.80, 5.59 ± 1.71, and 5.57 ± 1.43 μg/m3 for before, during, and post-pandemic, respectively. The level of TVOCs declined by − 43% for all monitoring stations during the lockdown period compared to the previous years. A higher T/B ratio was found in Patiala (2.97 μg/m3 ) before the pandemic, which may indicate vehicle emission sources. The LCR values for benzene were found to be higher in children than in males and females, which indicated the possible risk. The LCR values for benzene exceeded the prescribed value by CPCB for children.
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    Microbial World: Recent Developments in Health, Agriculture and Environmental Sciences
    (2021-03) Dhingra, G; Saxena, A; Nigam, A; Hira, P; Singhvi, N; Anand, S; Kaur, J; Kaur, J; Dua, A; Negi, N; Gupta, V; Sood, U; Kumar, R; Lal, S; Verma, H; Verma, M; Singh, P; Rawat, C; Tripathi, C; Talwar, C; Nagar, S; Mahato, N; Om Prakash; Singh, M; Kuhad, R.C.
    An Annual Conference Organized by Association of Microbiologists of India and Indian Network for Soil Contamination Research.