Browsing by Author "Beniwal, V"

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    Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
    (2023-04) Rippin; Beniwal, V; Sharma, A; Singh, B; Sharma, A
    Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit, seed, leaves, etc. Depending upon their structural composition, these polyphenols can be divided into two distinct groups, namely condensed tannins and hydrolysable tannins. Hydrolysable tannins can be further divided into two types: gallotannins and ellagitannins. Gallotannins are formed by the esterification of D-glucose hydroxyl groups with gallic acid. The gallolyl moieties are bound by a depside bond. The current review focuses mainly on the anti-carcinogenic potential of recently discovered gallotannins, ginnalin A, and hamamelitannin (HAM). Both of these gallotannins possess two galloyl moieties linked to a core monosaccharide having anti-oxidant, anti-inflammatory, and anti-carcinogenic abilities. Ginnalin A is found in plants of the genus Acer whereas HAM is present in witch hazel plants. The biosynthetic pathway of ginnalin A along with the mechanism of the anti-cancer therapeutic potential of ginnalin A and HAM has been discussed. This review will certainly help researchers to work further on the chemo-therapeutic abilities of these two unique gallotannins.
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    Using predictive models unravel the potential of titanium oxide loaded activated carbon for removal of leachate ammoniacal nitrogen
    (2024-05) Singh, K; Lohchab, R; Beniwal, V; Rout, C
    The TiO2 nanocomposite efficiency was determined under optimized conditions with activated carbon to remove ammoniacal nitrogen (NH3 -N) from the leachate sample. In this work, the facile impregnation and pyrolysis synthesis method was employed to prepare the nanocomposite, and their formation was confirmed using the XRD and Raman studies. In contrast, Raman phonon mode intensity ratio ID /IG increases from 2.094 to 2.311, indicating the increase of electronic conductivity and defects with the loading of TiO2 nanoparticles. The optimal conditions for achieving maximum NH3 -N removal of 75.8% were found to be a pH of 7, a dose of 1.75 mg/L, and a temperature of 30oC, with a corresponding time of 160 minutes. All adsorption isotherm records were properly fitted, and linear plots were utilized to analyze NH3 -N removal through adsorption kinetic models. Additionally, an effective central composite design (CCD) of response surface methodology (RSM) was employed to investigate the efficient removal of NH3 -N.